EFFECTS OF ISORHAPOTIGENIN AND RESVERATROL ON INTERLEUKIN 6 mRNA EXPRESSION FROM STIMULATED PERITONEAL MACROPHAGES OF MICE

AIM: Effects of isorhapotigenin and resveratrol on interleukin 6 mRNA expression from mouse peritoneal macrophages stimulated with fMLP and A₂₃₁₈₇ in succession were explored. METHODS: Interleukin 6 mRNA was semiquantified by RT-PCR. RESULTS: Isorhapotigenin and resveratrol, at the concentrations of 2×10^-6 and 2×10^-5 mol.L^-1, were shown to inhibit interleukin 6 mRNA expression from mouse peritoneal macrophages stimulated with fMLP or A₂₃₁₈₇ in succession. CONCLUSION: Inhibition of interleukin 6 mRNA expression may be the mechanism of the interleukin 6 biosynthetic inhibition of isorhapotigenin and resveratrol.