FAN Yun-Ge, JI Yao-Wu, HUANG Zhi-Xin , CHEN Heng-Chang, . SYNTHESES OF 1-(2-HYDROXY-3-ARYLOXYPROPYL)-4-AROYLPIPERAZINESJ. Acta Pharmaceutica Sinica, 1987, 22(3): 185-190.
Citation: FAN Yun-Ge, JI Yao-Wu, HUANG Zhi-Xin , CHEN Heng-Chang, . SYNTHESES OF 1-(2-HYDROXY-3-ARYLOXYPROPYL)-4-AROYLPIPERAZINESJ. Acta Pharmaceutica Sinica, 1987, 22(3): 185-190.
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SYNTHESES OF 1-(2-HYDROXY-3-ARYLOXYPROPYL)-4-AROYLPIPERAZINES

    Abstract
  • Nineteen 1-(2-hydroxy-3-aryloxypropyl)-4-aroylpiperazines were designed according to synbiotic approach and then synthesized. Eight of them (from I1 to I8) were subjected to preliminary pharmacological assay. They were shown to have α-adrenergic blocking and hypotensive activities.
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