SH Peng, YY Cui , TH Zhou, . STUDIES ON METABOLISM OF 6-METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMESJ. Acta Pharmaceutica Sinica, 1996, 31(7): 539-542.
Citation: SH Peng, YY Cui , TH Zhou, . STUDIES ON METABOLISM OF 6-METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMESJ. Acta Pharmaceutica Sinica, 1996, 31(7): 539-542.
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STUDIES ON METABOLISM OF 6-METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMES

    Abstract
  • 　The in vitro biotransformation of 6-methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3-OH-MBP, 6-OH-butyl phthalide and γ-OH-MBP. A less polar metabolite was tentatively identified as an epoxidation product.
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