STUDIES ON SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIMYCOPLASMA QUINOLONES

AIM: To develop new antimycoplasma drugs. METHODS and RESULTS: A series of new analogues of (_S)-(-)-ofloxacin with antimycoplasma activities were prepared. Compounds 18～24 were new compounds. Their _{in vitro} susceptibilities to mycoplama were tested. The influences on structure-activity relationships were also discussed. CONCLUSION: The synthesized compounds have good activities against mycoplasma. The electron-withdrawing groups on the 4-position of piperazine or homopiperazine may be favorable for antimycoplasma activity.