STUDIES ON PHARMACOKINETICS OF CISPLATINETHYLCELLULOSE MICROSPHERES FOR MAXILLARY ARTERIAL EMBOLIZATION IN DOGS

This paper reports the preparation and pharmacokinetic studies ofDDP - EC- ms. The DDP - EC- ms were infused into the maxillary artery of dogs andDDP were infused into the vein as control. The concentration of DDP in peripheralvenous blood and tissue was determined by FAAS. Results showed that the DDP level ofDDP - EC- ms in the circulating blood was significantly lower than that in dogs givenDDP intravenously. However, a significantly higher DDP concentration in tissues wasfound in dogs treated with DDP- EC-ms. These facts suggest that maxillary arterialembolization with DDP - EC - ms, which significantly reduced the systematic side effectsand increased the level of DDP in the embolized local tissue, could achieve the purpose oftargeted cancer therapy.