Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors

Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency   virus-1 (HIV-1) transcription.  PP1 is involved in the regulation of HIV-1 transcription, and dephosphorylates RNA polymerase II C-terminal domain (RNAPII CTD) or CycT1-dependent kinase 9 (CDK9) to increase Tat- dependent HIV-1 transcription.  In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors.