SYNTHESIS OF PORPHYRIN DERIVATIVES

This papar presents the preparation of eleven 2,4 or 6,7-substituted porphyrine derivives Ⅱ～Ⅻ from Ⅰ or diethyl ether of Ⅳ.The effects of these compouds, with irradiation, on DNA synthesis in L₁₂₁₀ cells were studied. The results showed that (1) all of these compounds were effective while (2) Va or Vb, Ⅵ and Ⅶ were more effective.