INHIBITORY EFFECT OF HYPOXANTHINE ON MONOAMINE OXIDASE ACTIVITY

Hypoxathine was demostrated to have a dose-dependent inhibitory effect on type B monoamine oxidase(MAO-B) activity in liver and brain tissues, and slight inhibitory effect on type A MAO(MAO-A) activity when given orally to mice at doses of 25～500 mg/kg. When mice were given orally hypoxanthine 500 mg/kg, MAO-A and-B activities were all inhibited significantly 16 hours after administration, but the inhibitory action on MAO-A was weaker. Subcutaneous injection of the agent also produced obvious inhibition of MAO activity in the liver but no significant influence on MAO activity in brain tissue was observed.In vitro experiment showed that the action of hypoxanthine on MAO-B was competitive inhibition and that on MAO-A was competitive mixed with noncompetitive inhibition.