STUDIES ON PULSED RELEASE TABLET OF VERAPAMIL HYDROCHLORIDE

AIM: To prepare an orally applicable pulsed release tablet, (PRT), which allows for rapid drug release after a predetermined lag time of 4 h. METHODS: Uniformed design was used to optimize the composition of the outer shell of dry coated tablet. γ-Scintigraphic evaluation and pharmacokinetic studies in dogs and humans were used to establish methodology capable of showing the subsequent in vivo performance of the pulsed release tablet. RESULTS: Multiple regression results can be used to design various pulsed release tablets with lag times of 3, 4 and 5 h. The result of the in vivo study suggested that formulation III in humans and formulation IV in dogs could be released after a lag time of 4 h. CONCLUSION: Pulsed release tablet prepared in the experiment only changed the time of pulsed release while C_max , AUC etc were not different from those of core tablet. The new system was useful to reduce the early morning symptoms of ischemic heart disease.