STUDIES ON STRUCTURE-ACTIVITY RELATIONSHIP OF ANALOGS OF TAPHA—A MAOI

4-Thioheptane-1,7-di-oyl-bis-isopropyl-hydrazide (Tapha, or CH-6) is a new monoamine oxidase inhibitor (MAOI) with low toxicity. With regard to inhibiting potency on MAO, there are a number of structural requirements which appear well defined (Ⅰ), such as thio-ether linkage, isopropyl group and propionyl (or acetyl) radical, beside the hydrazine moiety. Taphan acquires all these requirements (isopropyl, -S-, n=2), and its favourable pharmacological actions are understandable.