SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF 2-(2,4-DIFLUOROPHENYL)-3-(-N-METHYL-N-SUBSTITUTED ACYLAMINO)-1- (1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL

AIM: To search for high efficacy, low toxicity and broad spectrum antifungal drugs. METHODS: Twenty one new triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P450 14α demethylase, and their antifungal activities were determined by biological tests in vitro. RESULTS: Biological tests showed that all compounds have antifungal activity especially against Candida albicans and Candida parapsilosis. CONCLUSION: All target compounds could be regarded as potential inhibitors. Compound 15 exhibited high activity in all antifungal tests and was worthy of advanced study as a potential drug.