INHIBITION OF TUMOR INVASION AND METASTASIS BY RETINOID 4-APR

The anti invasive and anti metastatic effects with new retinoid 4-acetamidophenyl retinoate(4-APR) were studied using in vitro and in vivo experiments. 4-APR, at the dose of 43.3 mg·kg^-1 ·day^-1 po, was shown to reduce the spontaneous lung metastatic foci of Lewis lung carcinoma. 4-APR was also found to inhibit the artificial lung metastasis of B16-F10 cells by 67.9% and 36.6% and suppress the reconstituted basement membrane invasion of B16-F10 cells by 54.2% and 41.9% at the concentrations of 10^-5 mol·L^-1 and 10^-6 mol·L^-1, respectively.