Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus

AimTo study the microbial transformation of sinenxan A. MethodsChoose two strains of Fungi (Mucor spinosus AS 3.345 0 and Cunninghamella echinulata AS 3.340 0) and a strain of bacterium (Proteus vulgaris AS 1.120 8) to transform the substrate. ResultsThree products were obtained and identified as 10-deacetylsinenxan A1, 6α-hydroxy-10-deacetylsinenxan A2 and 9α-hydroxy-10-deacetylsinenxan A3 respectively. ConclusionSinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.