PERMEATION OF BUSPIRONE HYDROCHLORIDE ACROSS ANIMAL BUCCAL MUCOSA AND ITS MECHANISM

AIM To study the permeation of busprione hydrochloride across animal buccal mucosa and its permeation mechanism. METHODS The in vitro penetration model was designed to investigate drug buccal mucosa permeability, and the influence factors (different animal oral mucosa, such as rabbit, guinea pig, pig, sheep and cow, drug concentrations and solution pH values) were measured. RESULTS The permeability of rabbit buccal mucosa for busprione hydrochloride was the largest. The permeation rate was increased with solution pH and directly to the drug concentration. CONCLUSION The transport way of busprione hydrochloride was passive diffusion and the transport channel was through cells.