ZY Lu, SY Zhao, XM Yuan , YL Yang, . SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYLJ. Acta Pharmaceutica Sinica, 1990, 25(5): 336-339.
Citation: ZY Lu, SY Zhao, XM Yuan , YL Yang, . SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYLJ. Acta Pharmaceutica Sinica, 1990, 25(5): 336-339.
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SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYL

    Abstract
  • In the present paper, the synthesis and analgesic activities of some 4-N-propionyl analogs of 4-methoxycarbonyl fentanyl are reported. In mouse hot plate test, most of these compounds showed strong narcotic analgesic activity. The analgesic activitesof compounds 1379, 1385 and 1387 were found to be more potent than that of 4-methoxycarbonyl fentanyl.
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