EFFECT OF DL-3-BUTYLPHTHALIDE ON THE STRIATUM EXTKACELLULAR AMINO ACID AND DOPAMINE CONTENTS IN THE RAT DUKING CEREBRAL ISCHEMIA

The effect of dl-3-butyphthalide (NBP)on the contents of amino acids and dopamine in the rat striatum during globe cerebral ischemia has been studied.By using the technique ofmicroperfusion in the striatum of rats subjected to 4-vessel occlusion cerebral ischemia, theextracellular contents of glutamate,taurine,γ-aminobutyric acid and dopamine were found to besignificantly increased in the striatum during the 20 min of cerebral ischemia,NBP(40 mg·kg^-1, ip30 min before ischemia)was shown to reduce the contents of dopamine and its metabelite,3,4-dihydroxyphenylacetic acid(DOPAC),in the striatal extracellular fluid of the rat during ischemia,The content of glycine before and after ischemia was also reduced.However,no significant effect onthe contents of glutamate and some other amino acids was observed.The results suggest that NBP mayimprove the striatal ischemic injury.