SYNTHESIS OF DIACYLHYDRAZIDES OF 2-INDOLE AND THEIR PHYSIOLOGICAL ACTIVITY

Several diacyl (aroyl) hydrazides of 2-indole were synthesised by the reaction of 2-indolecarboxylic acid hydrazides with acyl (aroyl) chlorides (RCOCl or ArCOC1, R=H, CH₃, C₂H₅, CICH₂, CH₃(CH₂)₃, and Ar=4-Br-C₆H₄-or 3-C₅H₄N-) in anhydrous DMF or acetonitrile. It was found that when 2-indolecarboxylic acid hydrazide reacted with acetyl or propionyl chloride in acetonitrile, two other compounds were isolated. Their structures were established by ¹³C NMR spectroscopy.Formyl and acetylhydrazide of 2-indolecarboxylic acid and 2--5-(2-ethyl)-1,3,4oxadiazole-indole were shown to have bacteriostatic activity in vitro on Mycobacterium tuberculosis (Zopf.) Lehmann et Neumann.