IMPROVEMENT OF LEARNING AND MEMORY FUNCTIONS BY GABAB RECEPTOR ANTAGONISTS IN MICE

In one trial passive avoidance response in mice,the effects of γ-aminobutyric acid(GABA)_B receptor agonist baclofen and antagonist CGP₃₅₃₄₈ and CGP₃₆₇₄₂ on acquisition,consolidation and retrieval of memory were observed.The tesults showed that the antagonists couldsignificantly promote the acquisition impairment induced by baclofen, the consolidation impainnentinduced by baclofen and NaNO₂,and the retrieval impairment induced by baclofen and 30% alcohol.These results suggest that the GABA Breceptor antagonists may become a novel type of drug for thetreatment of Alzheimer'sdisease.