CHEMICAL CONSTITUENTS FROM MARINE FUNGUS PENICILLIUM THOMII

AIMTo investigate the bioactive constituents from the mycelium of Penicillium thomii. Which isolated from Anemone collected in Qingdao beach. METHODSThe constituents were separated by using various chromatography and the structures were identified on the basis of extensive spectral analysis. RESULTSFive compounds, namely penicillixanthone A (I), p-methylbenzolic acid (II), 1-O-hexadecanoyl-2-O-(9-octadecenoyl)-3-O-(9,12-octadecadienoyl) glycerol (III), 5α,8α-epidioxy-24ζ-methylcholesta-6,22-dien-3β-ol (IV) and 1,6,8-trihydroxyl-3-methyl-9,10-anthracenedione (V), were isolated from the mycelium of Penicillium thomii. CONCLUSIONPenicillixanthone A is a new compound, while the others are isolated from Penicillium thomii for the first time.