D Wei, YZ Jiang , ZZ Zhao, . SYNTHESIS OF ANALOGS OF CEPHALOTAXINE ESTERS AND THEIR ANTITUMOR ACTIVITIES.J. Acta Pharmaceutica Sinica, 1990, 25(9): 677-683.
Citation:
D Wei, YZ Jiang , ZZ Zhao, . SYNTHESIS OF ANALOGS OF CEPHALOTAXINE ESTERS AND THEIR ANTITUMOR ACTIVITIES.J. Acta Pharmaceutica Sinica, 1990, 25(9): 677-683.
D Wei, YZ Jiang , ZZ Zhao, . SYNTHESIS OF ANALOGS OF CEPHALOTAXINE ESTERS AND THEIR ANTITUMOR ACTIVITIES.J. Acta Pharmaceutica Sinica, 1990, 25(9): 677-683.
Citation:
D Wei, YZ Jiang , ZZ Zhao, . SYNTHESIS OF ANALOGS OF CEPHALOTAXINE ESTERS AND THEIR ANTITUMOR ACTIVITIES.J. Acta Pharmaceutica Sinica, 1990, 25(9): 677-683.
SYNTHESIS OF ANALOGS OF CEPHALOTAXINE ESTERS AND THEIR ANTITUMOR ACTIVITIES.
Four analogs, of cephalotaxine, esters: (C1 Z, C2 E, C3E, C4E) were synthesized. The ratio of the, Z, E isomers of the side chain α, β-unsaturated ester carboxylic acids is reported. The Z isomer was easy to transform to the E isomer.Compound C1Z showed significant activity of inducing cancer cell HL-60 differentiation. It also showed inhibitory activity on Leukemia L1210.
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