PIAO Zhi-Song, FENG E-Bing, WANG Lin, ZHANG Xin-Quan, LIN Mao. Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analoguesJ. 药学学报, 2010,45(12): 1509-1515.
Citation: PIAO Zhi-Song, FENG E-Bing, WANG Lin, ZHANG Xin-Quan, LIN Mao. Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analoguesJ. 药学学报, 2010,45(12): 1509-1515.
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Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues

    Abstract

  • Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1.  Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication.  Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 μmol·L−1.

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