KH Long, DL Jian , ZG Jian, . SYNTHESIS OF THE MARINE CYCLOPEPTIDE THIAZOLE AMINO ACID COMPONENT (D-VAL)THZJ. Acta Pharmaceutica Sinica, 1988, 23(4): 304-307.
Citation: KH Long, DL Jian , ZG Jian, . SYNTHESIS OF THE MARINE CYCLOPEPTIDE THIAZOLE AMINO ACID COMPONENT (D-VAL)THZJ. Acta Pharmaceutica Sinica, 1988, 23(4): 304-307.

SYNTHESIS OF THE MARINE CYCLOPEPTIDE THIAZOLE AMINO ACID COMPONENT (D-VAL)THZ

  • Thiazole amino acid is a key intermediate in the total synthesis of marine cyclopeptides: ulicyctamide, ulithiacyclamide, patellamides, ascidiacyclamide, dolatsatin. We have synthesized the (vla)thz by the following scheme:
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