STUDIES ON ANTIASTHMATIC AGENTS II. SYNTHESIS OF SOME ω-(3-HYDROXY-1, 4-NAPHTHO- QUINONYL-2)-ALKANOIC ACIDS AND MANNICH BASES OF 2-HYDROXY-l, 4-NAPHTHOQUINONE

To develop novel antiasthmatic agents other than the catecholamine group and without effect on adrenergic β₂ receptor, a series of naphthoquinone compounds (Ⅳ and Ⅴ) were synthesized. These compounds are structurally related both to a potent chromone compound (Ⅱ) reported in our previous paper and to some antiasthmatic active principles of Chinese traditional herbs. In addition, they can also be prepared as water-soluble salts for clinical use. The antiasthmatic tests of compounds Ⅳ and Ⅴ are in progress.