Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog

After oral administration of Salvia miltiorrhiza (Danshen in Chinese), Panax notoginseng (Sanqi in Chinese) and Danshen Sanqi combination suspensions to Beagle dogs, the plasma concentration-time profiles of danshensu, tanshinone Ⅱ_A, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1 and Rb1 were analyzed  by LC-MS/MS.  Pharmacokinetic parameters were calculated and analyzed with BAPP 2.0 software.  The   results showed that the C_max and AUC of danshensu, notoginsenoside R1, ginsenoside Rg1 and Rb1 in Danshen Sanqi combination group all decreased in comparison with those of Danshen or Sanqi given alone, while the CL_z/F and V_z/F increased to some extent.  No significant differences of the pharmacokinetics of tanshinone Ⅱ_A and cryptotanshinone were observed between groups.