STUDIES ON ANTIMALARIAL AGENTS——α-(ALKYLAMINOMETHYL)-HALOGENATED-4-FLUORENEMETHANOLS

Eight a-(alkylaminomethyl)-7-bromo-4-fluorenemethanols Ⅰ and twelve α-(alkylaminomethyl)-2,7-dichloro-4-fluorenemethanols Ⅱ have been synthesized and evaluated for antimalarial activity. Preliminary results Showed that some of these compounds displayed marked antimalarial activity against blood-induced plasmodium berghei in mice at 25 mg/kg.Compounds Ⅱ exhibited greater activity than compounds Ⅰ.The most active compounds were Ⅱ_g Ⅱ_h and Ⅱ_i which suppressed parasitemia at 5 mg/kg. None of these compounds showed any acute toxicity at the dosages tested.