Advances in the study of regulation of novel organic cation transporter-2

Novel organic cation transporter-2 (OCTN2), a member of the organic cation transporter family, may transport carnitine and multiple organic cationic drugs.  Thus OCTN2 possesses substantial roles in  physiology and pharmacology.  A number of researches have proven that many factors can regulate the expression and/or function of OCTN2 via different pathways, and then may affect the homeostasis and disposition of drugs.  This paper reviews recent progresses in this field.