SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES

HJ Fu; LY Zhu , ZY Lin

HJ Fu, LY Zhu , ZY Lin, . SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIESJ. Acta Pharmaceutica Sinica, 1996, 31(9): 715-720.

Citation:

HJ Fu, LY Zhu , ZY Lin, . SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIESJ. Acta Pharmaceutica Sinica, 1996, 31(9): 715-720.

Citation:

HJ Fu, LY Zhu , ZY Lin, . SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIESJ. Acta Pharmaceutica Sinica, 1996, 31(9): 715-720.

SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES

HJ Fu,
LY Zhu , ZY Lin,

Abstract

Abstract

Eighteen nicotinamides(I_1～12)and pyridylacrylamides(II_1～15)have beensynthesized. All synthesized amides were submitted to phannacological screening and 0.1um·L^-1(10^-7M)-noradrenaline induced contraction of the rat aortic strip was taken aS criterion,The amidesI_3,4 and II_1,2 showed more potent vasodilating activity than compounds I_12,13 and II_3,4.

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SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES

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