A STUDY OF THE INTRODUCTION OF N-BUTYL GROUP ONTO C17-POSITION OF ESTRADIOL——SYNTHESIS OF 17α-n-BUTYL-17β-ESTRADIOL-3-CYCLOPENTYL ETHER

MA Cheng-yu; CHEN Bang-ben; WANG Zhi-qing , MA Li-ren

MA Cheng-yu, CHEN Bang-ben, WANG Zhi-qing , MA Li-ren, . A STUDY OF THE INTRODUCTION OF N-BUTYL GROUP ONTO C17-POSITION OF ESTRADIOL——SYNTHESIS OF 17α-n-BUTYL-17β-ESTRADIOL-3-CYCLOPENTYL ETHERJ. Acta Pharmaceutica Sinica, 1983, 18(2): 144-146.

Citation:

MA Cheng-yu, CHEN Bang-ben, WANG Zhi-qing , MA Li-ren, . A STUDY OF THE INTRODUCTION OF N-BUTYL GROUP ONTO C17-POSITION OF ESTRADIOL——SYNTHESIS OF 17α-n-BUTYL-17β-ESTRADIOL-3-CYCLOPENTYL ETHERJ. Acta Pharmaceutica Sinica, 1983, 18(2): 144-146.

Citation:

MA Cheng-yu, CHEN Bang-ben, WANG Zhi-qing , MA Li-ren, . A STUDY OF THE INTRODUCTION OF N-BUTYL GROUP ONTO C17-POSITION OF ESTRADIOL——SYNTHESIS OF 17α-n-BUTYL-17β-ESTRADIOL-3-CYCLOPENTYL ETHERJ. Acta Pharmaceutica Sinica, 1983, 18(2): 144-146.

A STUDY OF THE INTRODUCTION OF N-BUTYL GROUP ONTO C₁₇-POSITION OF ESTRADIOL——SYNTHESIS OF 17α-n-BUTYL-17β-ESTRADIOL-3-CYCLOPENTYL ETHER

Abstract

Abstract

N-Butyl lithium has been proved to be a convenient reagent for introducing nbutyl group onto C₁₇-position of estrone-3-cyclopentyl ether. Using conventional Grignard's organomagnesium reagent we obtained 3-O-cyclopentyl-3,17β-estradiol instead of the normal adduct.