STUDIES ON ACYCLOVIR MULTIPLE EMULSION: ABSORPTION KINETICS, BIOAVAILABILITY AND HEPATIC TARGETING

AIM: To study the oral bioavailability and hepatic targeting of acyclovir (ACV) multiple emulsion in Sprague Dauley (SD) rats. METHODS: HPLC was testified as a potential method in assaying the concentration of ACV in plasma and tissue in rats after oral administration of multiple emulsion and tablet. Analysis of the data was executed by compartmental model and statistical moment calculation from which pharmacokinetic parameters were obtained. RESULTS: The relative availability of multiple emulsion to tablet was 149 8%. The t_max and maitaining time for ACV concentration in plasma were both delayed. The profile of the plasma concentration to time curve was fitted perfectly to two compartment open model. The hepatic drug distribution of multiple emulsion near the peak concentration was 1.62 folds that of the tablet (P<0.1), and the counterpart trough value was 4.16 folds bigger than tablet (P<0.05). CONCLUSION: Multiple emulsion administered orally to rats improved the relative bioavailability of the drug ACV and showed hepatic targeting nature to some extent in rats.