STUDY ON THE METABOLISM OF PSUEDO-GINSENOSIDE F11 IN RATS

AIM To study the metabolic pathways of psuedo ginsenoside F₁₁ in rats. METHODS By use of the prep-TLC, the metabolites were isolated. RESULTS From the feces, three metabolites, psuedo ginsenoside-R_T5, ocotillol, and a new compound, F-3-1 (44) were isolated and identified by means of NMR evidence. But, such metabolites were found from neither the bile nor the urine of the rat. F-3-1 was identified as 6-O-α-Lrhamnopyranosyl-(1-2)-β-D-glucopyranosyl-(20S,23S,24R)-dammar-20(24)-epoxy-3β,6α,12β,23,25-pentanol. CONCLUSION Psuedo ginsenoside-F₁₁ can not be metabolized in the rat liver, but can be metabolized in the large intestine of the rat.