NEUROPHARMACOLOGICAL ACTIONS OF SOME 5-HYDROXYTRYPTAMINE ANALOGUES

Neuropharmacological tests have been conducted in a series of 30 5-hydroxytryp- tamine analogues, including 2-dialkylamino derivatives of indole, benzofuran, benzimidazol or 2-methyl-3-dialkylamino derivatives of benzofuran. Compounds 2, 4, and 29 (Table 1) were shown to possess anticonvulsant activity against electroshock, the ED₅₀ being 10% or 20% of their LD₅₀ Compounds 1, 9, 10, 14 and 15 at 10^-3M exhibited an inhibition of in vitro monoamine oxidase activity, compound 10 still inhibited the enzyme activity at 10-⁵M. Most of the compounds were shown to stimulate isolated rat stomach fundus, but their actions were not antagonized by brom-LSD and are, therefore, presumably not related to the 5-hydroxytryptamine receptor.