A BIOGENETIC SYNTHESIS OF PROSTAGLANDIN E₁ METHYL ESTER

This paper reports a two step synthesis of prostaglandin E₁, that is (1) Oxidation of eicosatrienoic acid methyl ester with singlet oxygen and (2) potassium borohydride reduction. Finally, the product PGE₁ was separated by rotating thin layer chromatorgraphy on silica gel with a total yield about 5.8%. The data of IR, MS and NMR are the same as those in the literature.