TWO-SITE ABSORPTION MODEL FITS FO PHARMACOKINETIC DATA OF GEMFIBROZIL IN MAN

The plasma concentration-time data of gemfibrozil in 8 male subjects weredetermined after an oral dose of 600 mg.Two-peak concentrations in plasma were observed.A kind ofone-compartment model with two-sites of drug absorption was proposed and used to fit these data。Agood agreement between observed and predicted data was found in all subjects with correlation indexes(γ²)>0.99.The corresponding pharmacokinetic parameters were estimated as follows:T_max1,1.10±0.46h;T_max2,2.60±0.73h;C_max1,13.62±4.30μg·ml^-1;C_max2,17.22±3.83μg·ml^-1;T₁,0.06±0.06h;T₂,1.42±0.57h and T₃,1.79±0.60 h.