JL Pan, YG Wang , YZ Chen, . SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITROJ. Acta Pharmaceutica Sinica, 1997, 32(12): 898-901.
Citation: JL Pan, YG Wang , YZ Chen, . SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITROJ. Acta Pharmaceutica Sinica, 1997, 32(12): 898-901.
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SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITRO

    Abstract
  • A series of epipodophyllotoxin carboxylates were prepared from podophyllotoxin by reacting with organic acids under the catalysis of BF3·Et2O. All these products were characterized through IR, 1HNMR, MS and elemental analysis.These compounds showed significant antitumor activities against mouse leukemia P388 and human stomach cancer SGC-7901 in pharmacological tests in vitro.
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