Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs

 The metabolic transformation of the drugs containing carboxylic acid groups can lead to the  formation of acyl glucuronide metabolites through catalysis by glucuronosyltransferase, and produce pro-acyl glucuronide intermediate metabolites with electronic activity.  Then, protein or DNA adducts appeared after a series of non-enzyme or enzyme reactions.  These adducts would change the protein activity and potentially lead to idiosyncratic and genotoxicity.  In this paper, we discussed the chemical activity, drug-induced mechanisms, distribution and toxicity resulting from this metabolic activation for these drugs, and stated the status and   prospects of research in this field.