Tang Yuanqing, Wu Kemei Feng Xiaozhang , Huang Liang, . SYNTHESIS AND BIOACTION OF 2ALKYL4(1H)QUINOLONEJ. Acta Pharmaceutica Sinica, 1998, 33(2): 121-127.
Citation: Tang Yuanqing, Wu Kemei Feng Xiaozhang , Huang Liang, . SYNTHESIS AND BIOACTION OF 2ALKYL4(1H)QUINOLONEJ. Acta Pharmaceutica Sinica, 1998, 33(2): 121-127.
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SYNTHESIS AND BIOACTION OF 2ALKYL4(1H)QUINOLONE

    Abstract
  • Five quinolone alkaloids (IVa, Va,c,d,g) including two new compounds (IVa, Vc) from Evodia rutaecarpa and nine analogs are synthesized in good yield by using acidcatalyzed condensation of a series of 3oxoalkkanoic acid esters with aniline and further methylized with methyl iodide. The other analogue Vh is prepared through the reaction of lithium enolate methyl ketone with nmethylisatoic anhydride. Eight compounds (IVa,d,f; Vb,c,d,f,h) were synthesized for the first time. Pharmacological studies showed that these compounds have vasoconstriction inhibiting and antiulcer effects. Compound IVb also has cytotoxic effect.
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