STUDY ON ALBUMIN MICROSPHERES AS DRUG CARRIER FOR LIVER TARGETING

In this paper 6 factors and 12 levels of each variable were selected by Uniform Design Method and computer for preparing albumin microspheres with emulsion- chemical crosslinking. An optimal procedure for preparing albumin microspheres was established and the mean diameter of albumin microspheres is 0. 41～0. 47μm. Albumin was labelled with ¹²⁵Ⅰ-isotope and ¹²⁵Ⅰ-albumin microspheres were prepared according to the optimal procedure. The suspension of ¹²⁵Ⅰ-albumin microspheres with 0. 1% Tween-80 saline was injected Via mice tail vein. The animals were sequentially killed and the radioactivity of blood, spleen, liver, kidney, stomach, heart, lung, thyroid and brain were measured. The results showed that albumin microspheres were accumulated mainly in the liver, about 68% of the injected dose at the peak concentration. The pharmacokinetics of albumin microspheres in liver was also studied and twe--compartmental model can be used to describe the regulation.