Comparative study of lipophilicity from immobilized artificial chromatography and n-octanol/buffer systems

AimTo compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n-octanol/buffer systems.MethodsA test set consisted of 27 structurally diverse compounds.The lipophilicity of these were evaluated by both immobilized artificial memberane chromatography (IAMC) and n-octanol/buffer systems, which were expressed as lg kIAM and lg DO/W,7.4, respectively.Results With regard to each individual group, good correlation coefficient (r²) over 0.81 was obtained (0.82 for acid, 0.88 for neutral, 0.81 for base and 0.92 for ampholyte, respectively).However, a smaller r² (0.62) was acquired for all compounds studied than that of each individual group.ConclusionIAMC and n-octanol/buffer systems were shown to be different in lipophilicity.