STUDIES0N COMPOUNDS OF CANCER CHEMOPREVENTION:SYNTHESIS OF SOME AMIDES

In search for cancer chemoprevention agents, seven new amide compounds have been synthesized.The structures have been determined based on spectral and chemical data. N-4-(ethoxycarbophenyl)-α-naphthamide and N-4-(ethoxycarbophenyl)-β-naphthamide were shown to be81%and 79%effective,respectively,for inducing differention in HL-60 human promyclocyticleukemia cells at the concentration of 10^-5 mol/L in NBT tests.