| Citation: | ZHANG Jia-yu, TU Peng-fei. Construction and application of natural products LC-MS-DSJ. 药学学报, 2012,47(9): 1187-1192. |
To overcome the defects of current research methods of natural products, an LC-MS-DS that consisted of more than 600 natural products was constructed with HPLC-ESI-IT-MS/MS. The database searching results of LC-MS-DS were validated to be reliable, which indicated that LC-MS-DS could be successfully applied for the effective identification and target isolation of natural products. The study will provide an effective method for fast identification and efficient isolation of natural products.