THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS

By using optically pure R and S 3-quinuclidinols. two pairs of diastereoisomers (R-1) and (R-2), (S-1) and (S-2) were synthesized. Each pair was further separated by preparative TLC. The mobile phase was chloroform-methanol-ammonia water (8:2:0.07). There is a marked distinction among their affinities for M-cholinergic receptor in rat hrain The work is still in progress.