STUDIES ON TRITERPENOIDS AND THEIR GLYCOSIDES FROM ARALIA DASYPHYLLA MIQ

The structures of two triterpenoids and their glycosides were isolated from Aralia dasyphylla Miq. Their structures have been identified to be oleanoic acid(I), 16β-hydroxy-18β-H-oleanoic acid(II), oleanoic acid-28-O-β-D-glucopyranoside(III) and 16β-hydroxy-18β-H-oleanoic acid-28-O-β-D-glucopyranoside(IV), respectively, mainly through interpretation of UV, IR, MS, ¹H and ¹³CNMR, DEPT, HMQC and HMBC spectra data The stereochemistry of II has been confirmed by NOESY. Pharmacological experiments showed that the total saponins exerted preventative effect on CCl₄-induced liver injury of male mice and hypoglycemic effect on a model of alloxaninduced diabetes in rats.