STUDY ON PILULES OF INDOMETHACIN-PEG 6000

Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG6000as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twiceas much as pure IDM. When the effective dose of IDM -PEG 6000 was only half that ofIDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reducedsignificantly but it still manifested the action of inhibiting the secretion of basal gastricacid