CILIOTOXICITY OF PROPRANOLOL PREPARATIONS FOR INTRANASAL ADMINISTRATION

AIM: To screen a suitable dosage form for reducing ciliotoxicity of intranasal preparations. METHODS: Propranolol hydrochloride (PRO) was selected as a model drug and microspheres, multiple-emulsions and cyclodextrin inclusions for intranasal administration were prepared. The effect of the above preparations on ciliary movement was evaluated with in situ toad palate model. RESULTS: The microspheres were shown to be able to reduce the ciliotoxicity of PRO, but multiple-emulsions and cyclodextrin inclusions in this research were found to be inefficient because the embedding rate of the multiple-emulsions was low and the binding constant between PRO and cyclodextrin was small. CONCLUSION: The microspheres are an ideal dosage form for reducing ciliotoxicity and the involved mechanism is the sustained release effect of the microspheres.