XP Chen, QD Guo, , TS Shi. STUDIES ON TRANSDERMAL DELIVERY SYSTEM OF DIHYDROETORPHINE HYDROCHLORIDEJ. Acta Pharmaceutica Sinica, 1996, 31(10): 770-774.
Citation: XP Chen, QD Guo, , TS Shi. STUDIES ON TRANSDERMAL DELIVERY SYSTEM OF DIHYDROETORPHINE HYDROCHLORIDEJ. Acta Pharmaceutica Sinica, 1996, 31(10): 770-774.
shu

STUDIES ON TRANSDERMAL DELIVERY SYSTEM OF DIHYDROETORPHINE HYDROCHLORIDE

    Abstract
  • A transdermal delivery system of dihydroetorphine hydrochloride(DHE-TDS)wasdeveloped.The DHE-TDS mainly composed of polyvinyl alcohol,polyvinyl pyrrolidone and lactose.Tests on rabbits showed only slight skin irritation according to federal hazardous substances act Bygiving DHE-TDS to rabbits, DHE release was shown to be governed by first-order mechanism. WhenDHE-TDS was given to Wistar rats,a relatively stable blood drug concentration was observed from 4～32 h after drug adminstration. Writhing tests showed that one dose of DHE-TDS would maintainthe narcotic action on rats for at least 48 h.
    • FullText(HTML)
  • loading
    • References (0)
    • Relative Articles
  • Supplements (0)

Catalog

    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return