Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities

Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized.  All the structures were confirmed by ¹H NMR and MS.  The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay.  The results showed that these compounds    possessed moderate cytotoxities.