ELECTROCHEMICAL BEHAVIOR OF ADRIAMYCIN AND ITS APPLICATION AT Co/GC ION IMPLANTATION MODIFIED ULTRAMICROELECTRODE

AIM: To study the electrochemical behavior of adriamycin at Co/GC ion implantation modified ultramicroelectrode. METHODS: With Co/GC ion implantation modified ultramicroelectrode as working electrode, the behavior of adriamycin was studied by voltammetry in 0.1 mol.L^-1 HAc-NaAc (pH 4.73) solution. RESULTS: A sensitive reductive wave of adriamycin was obtained by linear sweep voltammetry. The peak potential was -0.520 V (vs.SCE). The peak current was proportional to the concentration of adriamycin over the range of 1.0×10^-7～2.0×10^-6 mol.L^-1 and 2.0×10^-6～1.0×10^-5 mol.L^-1 with the detection limit of 3.0×10^-8 mol.L^-1. The behavior of the reduction wave was studied and applied to the determination of adriamycin in human urine. CONCLUSION: The reduction process was quasi-reversible. The catalysis behavior and mechanism at Co/GC modified electrode were also studied.