Application of phosphates and phosphonates prodrugs in drug research and development

Based on the character of the molecular structure, the prodrugs of phosphates and phosphonates were divided into two categories.  The first is the drug which contained the phosphate group, introducing protected groups to increase lipophilicity and improve bioavailability.  The other one is the drug which had no phosphate group, introducing the phosphate group into molecules to enhance the solubility, regulate the distribution coefficient and enhance the drug-like property.  This review focuses on the application of phosphates and phosphonates in drug research and development based on improvement of physico-chemical property, drug safety and the pharmacokinetics.