BM Regmi, JP Liu , XD Tu, . STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACHJ. Acta Pharmaceutica Sinica, 1996, 31(1): 54-58.
Citation: BM Regmi, JP Liu , XD Tu, . STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACHJ. Acta Pharmaceutica Sinica, 1996, 31(1): 54-58.
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STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH

    Abstract
  • An oral sustained-release system of cthmozm0(E-HBS)was developed.The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics(Kr=0.2436h-1).The γ-scintiphotographic study showed that E-HBS remained in the human stomach formore than 6 hours after ingestion,much longer than the conventional tablet(1～1.5h).The plasmaconcentration-time curve of E-HBS exhibited typical sustained-release characteristics.The percentageof drug released in vitro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.
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