SYNTHESIS OF 2,6- DIMETHYL -4-DISUBSTITUTED PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATES AS ANTIMYOCARDIAL ISCHEMIC AGENTS

Nine title compounds were synthesized as potential antimyocardial ischemic agents. After screening, some of these compounds were found to exhibit calciumblocking activity. Among them, the antagonism of compound I₆ (diethyl 4- 3- methoxy-4- (2-hydroxy-3-isopropylamino )propoxy phenyl- 1,4-dihydropyridine- 3,5-dicarboxylates) was the most potent in the potassium-stimulated rabbit aortic strip.Compound I₆ was subjected to further pharmacological assay, and it was shown to increase coronary flow and cardiac output of isolated rabbit heart, reduce myocardial oxygen consumption, decrease myocardial infarct size of rat, and increase the tolerance of mice to hypoxia.